In 2007, the Ministry of Health and Long-Term Care announced the creation of 25 Nurse Practitioner-Led Clinics. The clinics were targeted to be fully operational by the end of 2012. To date, the 25 NPLCs are in various stages of development in the following communities: Barrie, Belle River Township of Lakeshore, Belleville, Capreol, Sudbury, Essex, French River, Huntsville, Ingersoll, Kitchener, London, Niagara Falls, North Bay, Oro Station, Oshawa, Peterborough, Sarnia, Sault Ste Marie, Scarborough, South Glengarry, Smith Falls, Sutton, Thessalon, Thunder Bay and Toronto.

Nurse Practitioner-Led Clinics are a new primary health care delivery model in which Nurse Practitioners are the lead providers of primary health care. Through a collaborative practice approach which includes Registered Nurses, Registered Practical Nurses, collaborating family physicians, and other health care professionals, nurse practitioners provide comprehensive, accessible, and coordinated family health care services. Nurse Practitioner-Led Clinics improve the quality of care through enhanced health promotion, disease prevention and chronic disease management, as well as improve care co-ordination and navigation of the health care system at the local level.